Recent Publications

Zhang, Y.; Matsuyama, H.; Shiratsuchi, T.; Tian, D.; Hook, D. J.; Walters, M. A.; Georg, G. I.; Hawkinson, J. E.; Hamazaki, T.; Terada, N. Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast. J Biomol Screen 2016.

Kurbanov, E. K.; Chiu, T.-L.; Solberg, J.; Francis, S.; Maize, K. M.; Fernandez, J.; Johnson, R. L.; Hawkinson, J. E.; Walters, M. A.; Finzel, B. C.; Amin, E. A. Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J. Med. Chem. 2015, 58, 8723-8733.

Dahlin, J. L.; Nissink, J. W. M.; Strasser, J. M.; Francis, S.; Higgins, L.; Zhou, H.; Zhang, Z.; Walters, M. A. PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS. J. Med. Chem. 2015, 58, 2091-2113.

Dahlin, J. L.; Nissink, J. W. M.; Francis, S.; Strasser, J. M.; John, K.; Zhang, Z.; Walters, M. A. Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR. Bioorg. Med. Chem. Lett. 2015, 25, 4740-4752.

Dahlin, J. L.; Inglese, J.; Walters, M. A. Mitigating risk in academic preclinical drug discovery. Nat. Rev. Drug Discov. 2015, 14, 279-294.

Dahlin, J. L.; Dahlin, J. L.; Walters, M. A. How to Triage PAINS-Full Research. Assay Drug Dev Technol 2015.

Dahlin, J. L.; Chen, X.; Walters, M. A.; Zhang, Z. Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases. Crit. Rev. Biochem. Mol. Biol. 2015, 50, 31-53.

Arrowsmith, C. H.; et al.; Walters, M. A.; Willson, T. M.; Workman, P.; Young, R. N.; Zuercher, W. J. The promise and peril of chemical probes. Nat Chem Biol 2015, 11, 536-541.

Maize, K. M.; Kurbanov, E. K.; De La Mora-Rey, T.; Geders, T. W.; Hwang, D.-J.; Walters, M. A.; Johnson, R. L.; Amin, E. A.; Finzel, B. C. Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr., Sect. D: Biol. Crystallogr. 2014, 70, 2813-2822.

Hassig, C. A.; Zeng, F.-Y.; Kung, P.; Kiankarimi, M.; Kim, S.; Diaz, P. W.; Zhai, D.; Welsh, K.; Morshedian, S.; Su, Y.; O'Keefe, B.; Newman, D. J.; Rusman, Y.; Kaur, H.; Salomon, C. E.; Brown, S. G.; Baire, B.; Michel, A. R.; Hoye, T. R.; Francis, S.; Georg, G. I.; Walters, M. A.; Divlianska, D. B.; Roth, G. P.; Wright, A. E.; Reed, J. C. Ultra-high-throughput screening of natural product extracts to identify proapoptotic inhibitors of Bcl-2 family proteins. J. Biomol. Screening 2014, 19, 1201-1211.

Dosa, P. I.; Georg, G. I.; Gurvich, V. J.; Hawkinson, J. E.; Walters, M. A.; Wong, H. L. From HTS to Phase I: The Institute for Therapeutics Discovery and Development at the University of Minnesota. Comb. Chem. High Throughput Screening 2014, 17, 231-240.

Dahlin, J. L.; Walters, M. A. The essential roles of chemistry in high-throughput screening triage. Future Med. Chem. 2014, 6, 1265-1290.

Dahlin, J. L.; Kottom, T.; Han, J.; Zhou, H.; Zhang, Z.; Walters, M. A.; Limper, A. H. Pneumocystis jirovecii Rtt109, a Novel Drug Target for Pneumocystis Pneumonia in Immunosuppressed Humans. Antimicrob Agents Chemother 2014, 58, 3650-9.

Dahlin, J. L.; Chen, X.; Walters, M. A.; Zhang, Z. Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases. Crit Rev Biochem Mol Biol 2014, 1-23.

Chou, T. F.; Bulfer, S. L.; Weihl, C. C.; Li, K.; Lis, L. G.; Walters, M. A.; Schoenen, F. J.; Lin, H. J.; Deshaies, R. J.; Arkin, M. R. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol 2014, 426, 2886-99.

Bosnakovski, D.; Choi, S. H.; Strasser, J. M.; Toso, E. A.; Walters, M. A.; Kyba, M. High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity. Skelet Muscle 2014, 4, 4.

Baell, J.; Walters, M. A. Chemistry: Chemical con artists foil drug discovery. Nature (London, United Kingdom) 2014, 513, 481-483.

Dosa, P. I.; Ward, T.; Walters, M. A.; Kim, S. W. Synthesis of Novel Analogs of Cabergoline: Improving Cardiovascular Safety by Removing 5-HT2B Receptor Agonism. ACS Med. Chem. Lett. 2013, 4, 254-258.

 

See also: http://www.ncbi.nlm.nih.gov/sites/myncbi/1pqTpKcqkjrQt/bibliography/47976875/public/?sort=date&direction=ascending