Barry Finzel

Barry Finzel, Professor

B.S. Chemistry Eastern Michigan University

Ph.D. Chemistry University of California San Diego (Joe Kraut, Adviser)

Interests: Structure-aided drug design. Antiviral and antibacterial Drug Discovery.  Protein substructure mining.  

Current Projects: Anthrax Lethal Factor Inhibition, Biotin Ligation and Biotin ligation in mTB, Protein substructure mining and superposition software develeopment 

Selected Publications:

T.Geders, K. Gustafson, B.Finzel. “Use of differential scanning fluorimetry to optimize purification and crystallization of PLP-dependent enzymes”. Acta Crystallogr. Sect F. 2012, 68(5):596-600. 

B.C. Finzel, R. Akavaram, A. Ragipindi, J.R. Van Voorst,  M. Cahn, M. Davis, M. Pokross, S. Sheriff, E.T. Baldwin.  "Conserved Core Substructures in the Overlay of Protein-Ligand Complexes". J. Chem Inf. & Modeling, 2011, 51:1931-1941. 

Z. Wang, W. Watt, N. Brooks, M.Harris, J.Urban, D.Boatman, M.McMillan, M.Kahn, R.Heinrikson, B. Finzel, J.Blinn, S.Kamtekar, A. Tomasselli. “Kinetic and Structural Characterization of Caspase-3 and Caspase-8 Inhibition by a Novel Class of Irreversible Inhibitors”.  Biochim. Biophys Acta. 2010, 1804, 1817-31. PMCID20580860.

T.-L. Chiu, J. Solberg, S. Patil, T. Geders, X. Zhang, S. Rangarajan, R. Francis, B. Finzel, M. Walters, D. Hook, E. Amin. Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening. J. Chem. Inform. Modelling, 2009, 49, 2724-36. PMCID19928768.

C. Deur, A.K. Agrawal, H.Baum, J.Booth, S.Bove, J.Brieland, A.Bunker, C.Connolly, J.Cornicelli, C.Deur, J.Dumin, B.Finzel, X.Gan, S.Guppy, G.Kamilar, K.Kilgore, P.Lee, C.-M.Loi, Z.Lou, M.Morris, L.Philippe, S.Przybranowski, F.Riley, B.Samas, B.Sanchez, H.Tecle, Z.Wang, K.Welch, M.Wilson, K.Yates.  (2007) “N- (6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)- N-alkylsulfonamides as Peripherally Restricted N-Methyl-D-Aspartate Receptor Antagonists for the Treatment of Pain”. Bioorganic & Medicinal Chemistry Letters, 17(16), 4599-4603.

J.A.Pfefferkorn, R.Nugent, R.J.Gross, M.L.Greene, M.A.Mitchell, M.T.Reding, L.A.Funke, R.Anderson. P.A.Wells, J.A.Shelly, R.A.Anstadt, B.C.Finzel, M.S.Harris, R.E.Kilkuskie, L.A. Kopta, F.J.Schwende (2005) “Inhibitors of HCV NS5B polymerase: Part 2: Evaluation of the northern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid”. Bioorganic & Medicinal Chemistry Letters, 15, 2812-2818.

J.A.Pfefferkorn, M.L.Greene, R.Nugent, R.J.Gross, M.A.Mitchell, B.C.Finzel, M.S.Harris, P.A.Wells, J.A.Shelly, R.A.Anstadt, R.E. Kilkuskie, L.A. Kopta, F.J.Schwende (2005) “Inhibitors of HCV NS5B polymerase: Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid”. Bioorganic & Medicinal Chemistry Letters, 15, 2481-2486.

BCFinzel, ET Baldwin, GL Bryant Jr., GF Hess, JW Wilks, CM Trepod, JE Mott, VP Marshall, G.L.Petzold, RA Poorman, TJ O'Sullivan, HJ Schostarez, MA Mitchell (1998) "Structural characterization of non-peptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.". Protein Sci., 7, 2118-2126.


  Kenneth Johnson, Post-doctoral Associate
 Teresa De la Mora-Rey Teresa De la Mora-Rey, Post-doctoral Associate
Ran Dai, Graduate Student
Li-Kai Liu, Graduate Student
  Kimberly  Maize, Graduate Student